Journal
CELL CALCIUM
Volume 56, Issue 6, Pages 437-445Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2014.10.003
Keywords
Mitochondria; Permeability transition; Reactive oxygen species; F-ATP synthase; Cancer
Categories
Funding
- FIRB/MIUR [RBAP11S8C3, RBLA03S4SP]
- PRIN/MIUR
- Progetti di Ateneo [CPDA123598]
- Progetti Strategici dell'Universita di Padova (Models of Mitochondrial Diseases)
- Associazione Italiana per la Ricerca sul Cancro [8722, 13392]
Ask authors/readers for more resources
This review covers recent progress on the nature of the mitochondrial permeability transition pore (PTP) - a key effector in the mitochondrial pathways to cell death - and on the adaptive responses of tumor cells that desensitize the PTP to Ca2+ and reactive oxygen species (ROS), thereby playing an important role in the resistance of tumors to cell death. The discovery that the PTP forms from dimers of F-ATP synthase; and the definition of the Ca2+- and ROS-dependent signaling pathways affecting the transition of the F-ATP synthase from an energy-conserving to an energy-dissipating device open new perspectives for therapeutic intervention in cancer cells. (C) 2014 The Authors. Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available