Journal
JOURNAL OF BACTERIOLOGY
Volume 185, Issue 22, Pages 6702-6706Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.185.22.6702-6706.2003
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The ability of Mycobacterium tuberculosis auxotrophs to survive long-term starvation was measured. Tryptophan and histidine auxotrophs did not survive single-amino-acid starvation, whereas a proline auxotroph did. All three auxotrophs survived complete starvation. THP-1 cells were also able to restrict the growth of the tryptophan and histidine auxotrophs.
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