Journal
CELL CALCIUM
Volume 52, Issue 1, Pages 28-35Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ceca.2012.03.003
Keywords
ATP; Mitochondria; Calcium; Heart; Beta cell; Islet; Insulin; Secretion; Diabetes
Categories
Funding
- Royal Society
- Juvenile Diabetes Research Foundation
- Wellcome Trust [081958/Z/07/Z]
- DiabetesUK [11/0004210]
- European Association for the Study of Diabetes (EFSD)
- British Heart Foundation
- Biotechnology and Biological Sciences Research Council
- Medical Research Council (U.K.)
- Wellcome Trust [081958/Z/07/Z] Funding Source: Wellcome Trust
- BBSRC [BB/J015873/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/J015873/1] Funding Source: researchfish
Ask authors/readers for more resources
Stimulation of mitochondrial oxidative metabolism by Ca2+ is now generally recognised as important for the control of cellular ATP homeostasis. Here, we review the mechanisms through which Ca2+ regulates mitochondrial ATP synthesis. We focus on cardiac myocytes and pancreatic beta-cells, where tight control of this process is likely to play an important role in the response to rapid changes in workload and to nutrient stimulation, respectively. We also describe a novel approach for imaging the Ca2+-dependent regulation of ATP levels dynamically in single cells. (C) 2012 Elsevier Ltd. All tights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
