Journal
CELL CALCIUM
Volume 50, Issue 3, Pages 211-221Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2011.03.003
Keywords
Apoptosis; Autophagy; Anoikis; AIF; Necrosis; Cell death mechanisms; Toxicity; Calcium; Phagocytosis
Categories
Funding
- Swedish Research Council
- Swedish Cancer Society
- Stockholm Cancer Society
- Swedish Childhood Cancer Foundation
- EC
- Russian Ministry of High Education and Science [11.G34.31.0006]
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Research during the past several decades has provided convincing evidence for a crucial role of the Ca2+ ion in cell signaling. Hence, intracellular Ca2+ transients have been implicated in most aspects of cell physiology, including gene transcription, cell cycle regulation and cell proliferation. Further, the Ca2+ ion has been found to also play an important role in cell death regulation. Thus, necrotic cell death was early associated with intracellular Ca2+ overload, and multiple functions in the apoptotic process have subsequently been found to be governed by Ca2+ signaling. More recently, other modes of cell death, notably anoikis and autophagic cell death, have been demonstrated to also be modulated by Ca2+ transients. Characteristics, interrelationship and mechanisms involved in Ca2+ regulation of these cell death modalities are discussed in this review. (C) 2011 Elsevier Ltd. All rights reserved.
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