Journal
CELL CALCIUM
Volume 50, Issue 2, Pages 147-156Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2010.12.007
Keywords
NAADP; cADPR; IP3; Ca2+; Sea urchin egg; Yolk platelets; Acidic Ca2+ stores; Endosomes; Lysosomes; Cortical granules; pH; Two-pore channel; TPC; Fertilization
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Sea urchin eggs have been an indispensable model system for studying egg activation and ionic signalling for at least a century. Instrumental in the discovery of two Ca2+-mobilizing second messengers, cyclic ADP-ribose and NAADP, the sea urchin has revolutionized cell biology for all phyla. This review attempts to summarize what we currently know about egg acidic vesicles in the context of Ca2+ signalling. The dynamics of Ca2+ storage, Ca2+ mobilization, proton fluxes and two-pore channels will be discussed. (C) 2011 Elsevier Ltd. All rights reserved.
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