Journal
INTERNATIONAL PSYCHOGERIATRICS
Volume 15, Issue 4, Pages 377-383Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1041610203009621
Keywords
dementia with Lewy bodies; REM sleep; donepezil; clonazepam; therapy
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Background: Dementia with Lewy bodies (DLB) is often associated with REM sleep behavior disorders (RBD) characterized, in contrast to the usual paralysis of REM sleep, by violent motor and verbal activity. Patients and Methods: The pharmacological management of RBD was investigated in three DLB patients treated with clonazepam, a benzodiazepine used as an antiepileptic, or donepezil, a cholinesterase inhibitor. Results: All three patients had marked improvement. The pharmacodynamic mechanisms underlying the efficacy of the two drugs might be due to facilitator effect on the pedunculopontine nucleus, a key structure in the physiology of REM sleep.
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