Journal
CELL CALCIUM
Volume 49, Issue 5, Pages 290-295Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ceca.2011.04.003
Keywords
Activity-regulated; Transcription; Calcium; Neuron; Calcium-response factor; BDNF
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Funding
- NIH [1-R01-DA022202]
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Calcium-response factor (CaRF) is a unique DNA-binding protein first recognized as a transcription factor for its role in modulating transcription of the gene encoding Brain-Derived Neurotrophic Factor (BDNF) in neurons. Here I review evidence for the biological functions and transcriptional targets of CaRF in the brain and discuss potential mechanisms by which calcium-activated signaling pathways may modulate CaRF-dependent transcription. These data paint an emerging picture of CaRF as a regulatory nexus for signaling pathways that control aspects of synaptic development and neuronal function. (C) 2011 Elsevier Ltd. All rights reserved.
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