Journal
CELL CALCIUM
Volume 50, Issue 2, Pages 157-167Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2011.03.011
Keywords
NAADP; Two-pore channels; TPC1; TPC2; TPCN1; TPCN2; Calcium; Endosomes; Lysosomes; Acidic calcium stores
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Funding
- BBSRC
- Wellcome Trust
- BBSRC [BB/G013721/1, BB/H009736/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G013721/1, BB/H009736/1] Funding Source: researchfish
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Accumulating evidence suggests that the endo-lysosomal system provides a substantial store of Ca2+ that is tapped by the Ca2+-mobilizing messenger, NAADP. In this article, we review evidence that NAADP-mediated Ca2+ release from this acidic Ca2+ store proceeds through activation of the newly described two-pore channels (TPCs). We discuss recent advances in defining the sub-cellular targeting, topology and biophysics of TPCs. We also discuss physiological roles and the evolution of this ubiquitous ion channel family. (C) 2011 Elsevier Ltd. All rights reserved.
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