Journal
CELL CALCIUM
Volume 49, Issue 5, Pages 323-330Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2011.05.004
Keywords
Cell cycle; Ca signaling; Gene expression; Fertilization; T-cell activation
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Funding
- NIH [GM61829]
- Qatar National Research Fund (QNRF) [NPRP08-395-3-088, NPRP08-138-3-050]
- Qatar Foundation
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Changes in the concentration and spatial distribution of Ca2+ ions in the cytoplasm constitute a ubiquitous intracellular signaling module in cellular physiology. With the advent of Ca2+ dyes that allow direct visualization of Ca2+ transients, combined with powerful experimental tools such as electrophysiological recordings, intracellular Ca2+ transients have been implicated in practically every aspect of cellular physiology, including cellular proliferation. Ca2+ signals are associated with different phases of the cell cycle and interfering with Ca2+ signaling or downstream pathways often disrupts progression of the cell cycle. Although there exists a dependence between Ca2+ signals and the cell cycle the mechanisms involved are not well defined and given the cross-talk between Ca2+ and other signaling modules, it is difficult to assess the exact role of Ca2+ signals in cell cycle progression. Two exceptions however, include fertilization and T-cell activation, where well-defined roles for Ca2+ signals in mediating progression through specific stages of the cell cycle have been clearly established. In the case of T-cell activation Ca2+ regulates entry into the cell cycle through the induction of gene transcription.
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