Journal
BRITISH JOURNAL OF CANCER
Volume 89, Issue 11, Pages 2116-2121Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6601372
Keywords
superficial oesophageal cancer; matrix metalloproteinase-7; matrix metalloproteinase-9; lymph node metastasis; prognostic factor
Categories
Ask authors/readers for more resources
If oesophageal carcinoma is detected in the superficial stage, the prognosis is better than for advanced oesophageal carcinoma. But the factors which predict the prognosis and treatment policy remain unclear. Matrix metalloproteinase-7 (MMP-7) and matrix metalloproteinase-9 (MMP-9) have been reported to have close associations with tumour invasion and metastasis. In this study, we retrospectively studied the relations between MMP-7 and MMP-9 expression in immunohistochemistry, clinicopathologic factors, and prognosis in 55 superficial oesophageal carcinomas. MMP-7 and MMP-9 expression occurred in 23.6% and 47.3% of the patients, respectively. MMP-7 expression was significantly correlated with the presence of nodal metastasis (P = 0.004). MMP-9 expression was significantly correlated with the depth of tumour invasion (P = 0.004), lymphatic permeation (P = 0.001), nodal metastasis (P = 0.049), and pathologic differentiation grade (P = 0.003). By the log-rank test, MMP-7 expression and MMP-9 expression on the invasive front were related to the prognosis. In multivariate analysis, MMP-9 expression on the invasive front was an independent prognostic indicator. The combined expression of MMP-7 and MMP-9 may be a good marker for the degree of malignancy of oesophageal cancer and for the presence of lymphatic metastasis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available