Journal
BIOCHEMICAL JOURNAL
Volume 369, Issue -, Pages 17-22Publisher
PORTLAND PRESS
DOI: 10.1042/BJ20021382
Keywords
diabetes; gluconeogenesis; HNF-4; gluconeogenesis; phosphoenolpyruvate carboxykinase
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Funding
- NIDDK NIH HHS [DK56374, P60 DK20593, 5 T 32 DK07563] Funding Source: Medline
- NIGMS NIH HHS [T32 GM62758] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [T32DK007563, R01DK056374, P60DK020593] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM062758] Funding Source: NIH RePORTER
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It has recently been shown that adenoviral-mediated expression of peroxisome proliferator-activated receptor gamma co-activator-1alpha (PGC-1 alpha) in hepatocytes stimulates glucose-6-phosphatase catalytic subunit (G6Pase) gene expression. A combination of fusion gene, gel retardation and chromatin immunoprecipitation assays revealed that, in H4IIE cells, PGC-1alpha mediates this stimulation through an evolutionarily conserved region of the G6Pase promoter that binds hepatocyte nuclear factor-4alpha.
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