Journal
INFECTION AND IMMUNITY
Volume 71, Issue 1, Pages 584-587Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.71.1.584-587.2003
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A whole-body mouse model of pneumonic melioidosis was established for future evaluation of biodefense vaccine candidates. The aerosol 50% lethal doses of Burkholderia pseudomallei strain 1026b for BALB/c and C57BL/6 mice and the times to death, dissemination in organs, and tissue loads after exposure of the mice to low- and high-dose aerosols are reported. In addition, rpsL mutant backgrounds were attenuated in this acute model of disease.
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