Journal
CELL BIOLOGY INTERNATIONAL
Volume 37, Issue 5, Pages 436-442Publisher
WILEY-BLACKWELL
DOI: 10.1002/cbin.10057
Keywords
Aurora B; chromosome passenger; spindle; microtubule plus ends; mitosis
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Funding
- National Natural Science Foundation of China [81101871, J1103503]
- PhD Launch Fund of TJCIH
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The spindle, composed of microtubules and associated proteins, serves as major machinery for cell division. Aurora B is a chromosome passenger protein that has important functions in mitosis. Its dynamic distribution at mitosis goes along with spindle structure and dynamics. We used the siRNA technique to knockdown protein expression and immunofluorescence technique to follow Aurora B during mitosis. Aurora B regulates microtubule plus ends as mitosis progresses, including both kinetochore and polar microtubules. Interactions between Aurora B and polar microtubule plus ends lead to failure in cytokinesis and abnormal midbody structure. We think Aurora B may not only play a role as kinase, but regulate microtubule plus ends.
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