Journal
APPLIED OPTICS
Volume 42, Issue 1, Pages 124-134Publisher
OPTICAL SOC AMER
DOI: 10.1364/AO.42.000124
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Methods for local photon path length and optical properties estimation, based on measured and simulated diffuse reflectance within 2 min from the light source, are proposed and evaluated in vivo on Caucasian human skin. The accuracy of the methods was good (2%-7%) for path length and reduced scattering but poor for absorption estimation. Reduced scattering and absorption were systematically lower in the fingertip than in the forearm skin (633 nm). A maximum intrasite and interindividual variation of similar to35% in an average photon path length was found. The methodology was applied in laser Doppler flowmetry, where path-length normalization of the estimated perfusion removed the optical property dependency. (C) 2003 Optical Society of America.
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