4.4 Article

Dynein LIC1 localizes to the mitotic spindle and midbody and LIC2 localizes to spindle poles during cell division

Journal

CELL BIOLOGY INTERNATIONAL
Volume 35, Issue 2, Pages 171-178

Publisher

PORTLAND PRESS LTD
DOI: 10.1042/CBI20100284

Keywords

cytokinesis; DLIC; dynein light intermediate chain; LIC1; LIC2; mitosis

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Funding

  1. Science Foundation Ireland (SFI) [05/IN.3/B859, 08/RFP/NSC 1499]

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CD-1 (cytoplasmic dynein-1) is a multisubunit motor protein complex involved in intracellular trafficking and mitosis. The dynein LIC (light intermediate chain) subunits, LIC1 (DLIC-1, gene symbol DYNC1LI1) and LIC2 (DLIC-2, gene symbol DYNC1LI2), associate with the dynein HC (heavy chain) in a mutually exclusive manner and thus define distinct functional CD-1 complexes. Here, we analysed the mitotic distribution of LIC1 and LIC2. We found that from metaphase through anaphase, LIC1 localizes to the mitotic spindle and concentrates within the midbody during the abscission step of cytokinesis. Conversely, LIC2 strongly localizes to the spindle poles from prophase through telophase. These data suggest distinct functions for LIC1 and LIC2-containing CD-1 complexes during cell division.

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