Journal
CELL BIOLOGY INTERNATIONAL
Volume 35, Issue 5, Pages 491-497Publisher
WILEY
DOI: 10.1042/CBI20090419
Keywords
apoptosis; ESCC; hypoxia; proliferation; YC-1
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Funding
- National Natural Science Foundation of China [30770991, 30800511]
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HIF-1 alpha: (hypoxia-inducible factor 1 alpha) is believed to promote oesophageal squamous tumour growth. Thus, an HIF-1 alpha inhibitor is viewed as a therapeutic target in treating oesophageal cancer. Recently, YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] has been widely used as a potential HIF-1 alpha inhibitor and is being developed as a novel anticancer drug. However, little is known about the effects of YC-1 in human oesophageal cancer. In the present study, we aimed to investigate these effects in an esophageal squamous cancer cell line; i.e. Eca109 cells. We found that YC-1 abolished the hypoxia-induced up-regulation of HIF-1 alpha. YC-1 arrested cell growth and inhibited cell migration activities in Eca109 cells. These results suggest that YC-1 may be a chemotherapy candidate against oesophageal squamous cancers.
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