Journal
CELL BIOLOGY INTERNATIONAL
Volume 34, Issue 12, Pages 1231-1238Publisher
WILEY
DOI: 10.1042/CBI20100531
Keywords
artery; disease; endothelial cell; endothelial progenitor cell; vein
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Funding
- German Federal Ministry of Education and Research [01ZZ0502]
- DFG [MO 1695/4-1]
- European Union
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The endothelium is a dynamic, heterogeneous, disseminated organ that possesses vital secretory, synthetic, metabolic and immunological functions. Endothelial dysfunction has been implicated as a key factor in the development of organ-specific vascular diseases. This minireview gives a brief overview on EC (endothelial cell) biomarkers in arterial and venous endothelium and critically discusses the different sources of ECs that are most frequently applied in in vitro assays and research. The relevance of organ- and disease-specific endothelial cell cultures for studying cellular responses as a basis for improving therapeutic interventions is highlighted with particular emphasis on endothelial dysfunction in transplant-associated coronary artery disease, in atherosclerotic lesions and in response to diabetes mellitus.
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