Journal
CELL BIOLOGY INTERNATIONAL
Volume 33, Issue 2, Pages 135-147Publisher
WILEY
DOI: 10.1016/j.cellbi.2008.10.005
Keywords
Rheumatoid arthritis (RA); Synovial fibroblast (SFB); Luteolin; Collagen-induced arthritis (CIA); Proliferation
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Funding
- Science and Technology Department of Shanghai Research Foundation [05DZ19339]
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Hyperproliferation of synovial fibroblasts is considered to be a pivotal event in the pathogenesis of rheumatoid arthritis (RA). Luteolin, a flavonoid, inhibits the proliferation of synovial fibroblasts in collagen-induced arthritic rats. Treatment with luteolin also decreases the secretion of matrix metalloprotease-1 and -3 and the expression of IL-6, IL-8, IL-15, and TGF-beta. Luteolin treatment caused a delay of cells in the G(2)/M phase. Interestingly, combination treatment with luteolin and TNF-alpha exhibited a synergistic inhibitory effect in all experiments. Western blotting demonstrated that treatment with luteolin alone or combined with TNF-alpha inhibited the MAPK/ERKs and PI3K-Akt pathways. These results indicate that luteolin inhibits the proliferation and partially blocks the pathogenic function of synovial fibroblasts in rheumatoid arthritis. (C) 2008 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
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