Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 684, Issue 1-2, Pages 50-55Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/S0022-328X(03)00503-5
Keywords
aryl halides; benzonitriles; cyanation; homogeneous catalysis; palladium; trimethylsilylcyanide
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Benzonitriles are easily accessible from the corresponding aryl bromides in a palladium-catalyzed reaction using trimethylsilylcyanide (TMSCN) as cyanating agent under mild conditions. The key of success for the cyanation protocol is the slow dosage of the TMSCN to the reaction mixture. This new method is applicable to both activated and deactivated aryl and heteroaryl bromides giving the corresponding benzonitriles in good to excellent yields. (C) 2003 Elsevier B.V. All rights reserved.
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