Journal
CELL BIOLOGY INTERNATIONAL
Volume 32, Issue 1, Pages 157-162Publisher
WILEY
DOI: 10.1016/j.cellbi.2007.08.021
Keywords
Kaposi sarcoma; Immune cell infiltrate; Nodular lesions
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Typically, Kaposi's sarcoma (KS) also presents with immune cell infiltrates. This study does immunophenotype characterization for demographics of some of these cells to test the hypothesis that 'development of end-stage (nodular/ tumor) KS is associated with numeric alteration in immune cell infiltrates.' Fifteen cases of classic-KS (nodular/ tumor) and 20 normal biopsies were examined using antigen-antibody reactions and immunoperoxidase staining for histiocytes (CD68), B cells (CD20) and T cells (CD3). Variations between normal and lesions were observed with significant increases in immune cell infiltrates (2.3 +/- 0.6 vs. 6.4 +/- 0.4); CD68(+) (4.0 +/- 1.0 vs. 7.0 +/- 0.5); CD3(+) (3.0 +/- 1.1 vs. 10.1 +/- 0.8); and CD20(+) (0.0 +/- 0.0 vs. 0.3 +/- 0.0). Increased density of immune cells in the nodular lesions of KS may reflect increased antigenicity of these lesions; the increase in T cells suggests enhanced T cell activity in KS. However, these issues should be tested by further studies. (C) 2007 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
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