In vitro activity of tigecycline against Staphylococcus epidermidis growing in an adherent-cell biofilm model

The activity of tigecycline against Staphylococcus epidermidis growing in an in vitro adherent-cell biofilm model was determined. Tigecycline minimum bactericidal concentrations (MBCs) ranged from 1 to 8 mug/ml for S. epidermidis growing in a biofilm of adherent cells, compared to MBCs of 0.12 to >32 mug/ml for freely growing cells. The killing activity of tigecycline against the adherent bacteria was at least fourfold better than that of vancomycin and daptomycin.