4.6 Article

Glycosyl phenylthiosulfonates (Glyco-PTS): novel reagents for glycoprotein synthesis

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 1, Issue 21, Pages 3642-3644

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b306990g

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Funding

  1. Biotechnology and Biological Sciences Research Council [EGA17763] Funding Source: Medline

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Controlled site-selective glycosylation can be achieved by combining site-directed cysteine mutagenesis with chemical modification of the introduced thiol; a new class of more efficient chemoselective reagents, glycosyl phenylthiosulfonates, allow rapid glycosylations of representative simple thiols, peptides and proteins.

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