4.3 Article

Solvent effect in the Wittig reaction under Boden's conditions

Journal

SYNTHETIC COMMUNICATIONS
Volume 33, Issue 13, Pages 2187-2196

Publisher

MARCEL DEKKER INC
DOI: 10.1081/SCC-120021496

Keywords

stereochemical control; Wittig olefination

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An interesting change in the stereochemical outcome of the Wittig olefination reaction under Boden's conditions (potassium bases and 18-crown-6 as the ylide forming reagent) is reported. This effect depends significantly on the polarity of the solvents and the nature of the ylide.

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