4.6 Article

The Co(I) induced methylmalonyl-succinyl rearrangement in a model for the coenzyme B-12 dependent methylmalonyl-CoA mutase

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 1, Issue 18, Pages 3154-3159

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b305782h

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The rearrangement of 2-bromomethyl-2-methylmonothiomalonates to succinyl derivatives was found to take place in quantitative yields in the presence of one molar equivalent of Co(I) generated by the reduction of heptamethyl Co(II) yrinate perchlorate with NaBH4 or electrochemically. The chiral thiomalonate gave racemic succinate.

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