Gadolinium-labeled dendrimers as biometric nanoprobes to detect vascular permeability

PAMAM dendrimer-based biometric nanoprobes G4-1B4M-Gd, G6-1B4M-Gd and G8-1B4M-Gd were used to detect vascular permeability in SCCVII mice tumors. Based on the whole body clearance curve, G8-1B4M-Gd emerged as the ideal candidate for vascular permeability imaging studies due to its stable signal enhancement in the tumor over time. A 2D MR image of a SCCVII tumor showed vessel enhancement without obvious diffuse enhancement.