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JOURNAL OF PEDIATRICS
Volume 143, Issue 5, Pages 605-608Publisher
MOSBY-ELSEVIER
DOI: 10.1067/S0022-3476(03)00535-3
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Objective: To analyze prospectively the impact of age at diagnosis in childhood idiopathic thrombocytopenic purpura (ITP). Study design: International registry from June 1997 to May 2001, with analysis of data from baseline and 6-month-follow-up questionnaires. Results: Data from 2540 patients were analyzed, including 203 infants (7.6%), 1860 children greater than or equal to l to < 10 years of age (69.1%), and 477 children and adolescents between greater than or equal to 10 and < 16 years of age (17.7%). The mean platelet count at diagnosis was similar in all three groups, as was the percentage of patients with initial platelet count < 20 X 10(9)/L. The male/female ratio was highest in infants and decreased with age (P = .009). Immunoglobulin therapy was used more often in infants and corticosteroids in patients greater than or equal to 10 years of age. Follow-up information at 6 months was available for 1742 children (68.6%). Chronic ITP was seen less frequently in infants (23.1%) than in children > 10 years of age (47.3%, P < .0001). Intracranial hemorrhage occurred in 3 of 1742 children during the first 6 months after the diagnosis of ITP. Conclusions: Pediatric patients with ITP from infancy to adolescence exhibit heterogeneity in clinical, demographic, and treatment factors.
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