Journal
JOURNAL OF GENERAL VIROLOGY
Volume 84, Issue -, Pages 2987-2992Publisher
SOC GENERAL MICROBIOLOGY
DOI: 10.1099/vir.0.19252-0
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Funding
- NATIONAL CANCER INSTITUTE [T32CA009560, R01CA062234, R01CA073507, R01CA093444] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE013127] Funding Source: NIH RePORTER
- NCI NIH HHS [CA62234, CA93444, T32CA009560, CA73507] Funding Source: Medline
- NIDCR NIH HHS [DE13127] Funding Source: Medline
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Epstein-Barr virus (EBV) infection is a multi-step process, first requiring virus binding to the host cell, followed by fusion of the viral envelope with the host cell plasma membrane. Efficient EBV entry into B cells requires, at the minimum, the interaction of the EBV-encoded glycoproteins gp350 with cellular CD21 and gp42 with MHC class II proteins. In this study, use of the cholesterol-binding drugs methyl-beta-cyclodextrin and nystatin efficiently inhibited EBV infection of target Burkitt's lymphoma B-cell lines, indicating an important role for cholesterol and suggesting the involvement of lipid rafts in EBV infection.
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