Journal
JOURNAL OF NEUROSCIENCE RESEARCH
Volume 74, Issue 3, Pages 430-434Publisher
WILEY-BLACKWELL
DOI: 10.1002/jnr.10786
Keywords
matrix metalloproteases; plasminogen activators; sciatic nerve; nerve regeneration
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Funding
- NICHD NIH HHS [T32-HD07408] Funding Source: Medline
- NINDS NIH HHS [NS44129, T32-NS07083] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [T32HD007408] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS044129, T32NS007083] Funding Source: NIH RePORTER
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Plasminogen activators (PAs), tissue PA (tPA) and urokinase PA (uPA), have been shown to be induced in sensory neurons after sciatic nerve crush. These findings suggested that PAs facilitate peripheral nerve regeneration by digesting adhesive cell contacts and by activation of other proteases, thereby initiating a proteolytic cascade. Both tPA and uPA activate some matrix metallo-proteases (MMPs), indirectly via plasminogen activation or directly, such as the uPA activation of MMP-2. In this study, we demonstrated, by using tPA and uPA knockout mice, that a lack of a plasminogen activator affected MMP-9 and MMP-2 activity after crushing of the sciatic nerve. These findings show that the PAs are important for MMP-9 and MMP-2 activity at the crush site. (C) 2003 Wiley-Liss, Inc.
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