Journal
JOURNAL OF CELL SCIENCE
Volume 116, Issue 21, Pages 4277-4281Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.00816
Keywords
cytokinesis; Rho GTPase; PBL/Ect2 RhoGEF; contractile ring; PAV-KLP/MKLP1; central spindle; microtubules
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Despite a century of research into the nature of animal cell division, a molecular explanation for the positioning of the actomyosin contractile ring has remained elusive. The discovery of a novel interaction between regulators of Rho family small GTPases has revealed a link between the mitotic microtubules and the contractile ring during the later stages of mitosis. The properties of the interacting Rho regulators suggest a molecular model for the positioning and initiation of contractile ring furrowing in animal cells. In this 'double ring' model, centralspindlin complexes, localized by the action of their kinesin-like protein component, position and activate a cortical equatorial ring of Rho GTPase exchange factors. The resulting ring of activated Rho would then trigger a cascade of events leading to formation and constriction of the contractile ring.
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