Journal
JOURNAL OF NATURAL PRODUCTS
Volume 66, Issue 11, Pages 1515-1516Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np0303106
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Funding
- FIC NIH HHS [1 U01-TW01021-01] Funding Source: Medline
- FOGARTY INTERNATIONAL CENTER [U01TW001021] Funding Source: NIH RePORTER
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A new cucurbitacin D analogue, 2-deoxycucurbitacin D (1), as well as cucurbitacin D (2) and 25-acetylcucurbitacin F (3) were isolated from Sloanea zuliaensis. Compound 1 was found only in the young leaves of the plant and not in the mature leaves, and its structure was established using spectroscopic means. Compounds 1-3 demonstrated potent cytotoxic activity against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines.
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