Journal
BIOTECHNOLOGY LETTERS
Volume 25, Issue 21, Pages 1827-1831Publisher
SPRINGER
DOI: 10.1023/A:1026281914301
Keywords
bioconversion; compactin; cytochrome P-450; pavastatin; Streptomyces sp.
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Streptomyces sp. Y-110, isolated from soil, modified compactin to pravastatin, a therapeutic agent for hypercholesterolemia. In a batch culture, the highest production of pravastatin was 340 mg l(-1) from 750 mg compactin l(-1) in 24 h. By intermittent feeding of compactin into the culture medium, both the compactin concentration and its conversion increased to 2000 mg l(-1) and 1000 mg pravastatin l(-1), respectively, with the conversion rate of 10 mg l(-1) h(-1). Continuous feeding of compactin increased production of pravastatin to 15 mg l(-1) h(-1).
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