4.3 Article

Quercetin Potentiates the Antitumor Activity of Rituximab in Diffuse Large B-Cell Lymphoma by Inhibiting STAT3 Pathway

Journal

CELL BIOCHEMISTRY AND BIOPHYSICS
Volume 70, Issue 2, Pages 1357-1362

Publisher

HUMANA PRESS INC
DOI: 10.1007/s12013-014-0064-8

Keywords

Quercetin; Rituximab; STAT3; DLBCL

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STAT3 pathway plays an important role in the growth of diffuse large B-cell lymphoma (DLBCL) cells. Here we investigated the antitumor activity of Quercetin, a flavonoid compound, in combination with rituximab in DLBCL cell lines in vitro. We found that Quercetin synergistically enhanced rituximab-induced growth inhibition and apoptosis in DLBCL cell lines. Moreover, we found Quercetin exerted inhibitory activity against STAT3 pathway and downregulated the expression of survival genes. These results suggest that combining the Quercetin with rituximab may present an attractive and potentially effective way for the treatment of DLBCL.

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