Journal
ELECTROPHORESIS
Volume 24, Issue 21, Pages 3689-3693Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elps.200305536
Keywords
microchip; microfluidic; miniaturization; monolith; porous polymer
Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM048364] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM-48364] Funding Source: Medline
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UV-initiated grafting of plastic tubes and microfluidic chips with ethylene diacrylate followed by the preparation of porous polymer monoliths has been studied. The first step affords a thin grafted layer of polymer with a multiplicity of pendent double bonds that are then used in the second step for covalent attachment of the monolith to the wall. As clearly seen on scanning electron micrographs, this procedure prevents the formation of voids at the monolith-channel interface a problem that has always plagued approaches involving bulk polymerization in nontreated channels due to the shrinkage of the monolith during the polymerization process and its lack of compatibility with the material of the device. Irradiation with UV light through a photomask allows precise patterning specifying both the area subjected to surface modification and the location of the monolith within specific areas of the device.
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