Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 112, Issue 11, Pages 1603-1618Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI200320401
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Funding
- NCI NIH HHS [CA75979, R01 CA075979] Funding Source: Medline
- NIDDK NIH HHS [DK64169, R01 DK064169] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA075979] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK064169] Funding Source: NIH RePORTER
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The anterior pituitary gland integrates the repertoire of hormonal signals controlling thyroid, adrenal, reproductive, and growth functions. The gland responds to complex central and peripheral signals by trophic hormone secretion and by undergoing reversible plastic changes in cell growth leading to hyperplasia, involution, or benign adenomas arising from functional pituitary cells. Discussed herein are the mechanisms underlying hereditary pituitary hypoplasia, reversible pituitary hyperplasia, excess hormone production, and tumor initiation and promotion associated with normal and abnormal pituitary differentiation in health and disease.
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