Journal
CELL BIOCHEMISTRY AND BIOPHYSICS
Volume 70, Issue 1, Pages 505-509Publisher
HUMANA PRESS INC
DOI: 10.1007/s12013-014-9948-x
Keywords
BRSM1; Rectal cancer; Metastasis
Funding
- National Natural Science Foundation of China [30770103]
- Shandong Province Natural Science Foundation [Y2007C118]
- Shandong Science and Technology Development Plan [2011GGC03078]
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Breast cancer metastasis suppressor gene-1 (BRMS1) is newly discovered tumor metastasis gene, which has been reported to play an important role in the progression of human tumor. However, its role in rectal cancer has never been investigated. In this present study, we evaluated the associated of BRMS1 with colorectal cancer, its value in prognosis, and its role in metastasis of rectal cancer. BRMS1 expression examined in 80 patients and the role of BRMS1 in metastasis was studied using mice model. Our results showed that BRMS1 expression was significantly associated with clinicopathological parameters in rectal cancer patients and overexpression of BRMS1 in rectal cancer xenograft led to decreased growth, invasiveness and metastasis. Our findings indicate that high expression of BRSM1 in rectal cancer plays an essential role in tumor progression.
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