Related references
Note: Only part of the references are listed.TAK1 ubiquitination regulates doxorubicin-induced NF-κB activation
Li Liang et al.
CELLULAR SIGNALLING (2013)
Regulation of DNA Damage Responses by Ubiquitin and SUMO
Stephen P. Jackson et al.
MOLECULAR CELL (2013)
Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7
Yingnan Zhang et al.
NATURE CHEMICAL BIOLOGY (2013)
Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress
R. M. Jones et al.
ONCOGENE (2013)
Ubiquitin-Like Proteins
Annemarthe G. van der Veen et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)
The Ubiquitin System, an Immense Realm
Alexander Varshavsky
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)
The Ubiquitin Code
David Komander et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)
Exploiting the Cancer Genome: Strategies for the Discovery and Clinical Development of Targeted Molecular Therapeutics
Timothy A. Yap et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 52 (2012)
Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration
Ning Xiao et al.
BIOCHEMICAL JOURNAL (2012)
Histone marks: repairing DNA breaks within the context of chromatin
Kyle M. Miller et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2012)
Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases
Ji-Young Park et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2012)
Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors
Masaharu Uno et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK)
Christopher W. Davies et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation
Anastasia Nijnik et al.
BLOOD (2012)
Genetic disruption of USP9X sensitizes colorectal cancer cells to 5-fluorouracil
Dennis R. Harris et al.
CANCER BIOLOGY & THERAPY (2012)
A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance
Dharminder Chauhan et al.
CANCER CELL (2012)
RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling
Francesca Mattiroli et al.
CELL (2012)
Attenuation of the ubiquitin conjugate DNA damage signal by the proteasomal DUB POH1
Joanna R. Morris
CELL CYCLE (2012)
Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes
Olga A. Issaenko et al.
CELL CYCLE (2012)
Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme
Celine Reverdy et al.
CHEMISTRY & BIOLOGY (2012)
Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1
Xiao-Xin Sun et al.
EMBO JOURNAL (2012)
Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability
Mathew J. K. Jones et al.
EMBO JOURNAL (2012)
The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response
Laura R. Butler et al.
EMBO JOURNAL (2012)
RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair
Yaron Galanty et al.
GENES & DEVELOPMENT (2012)
Molecular Basis of Lys-63-linked Polyubiquitination Inhibition by the Interaction between Human Deubiquitinating Enzyme OTUB1 and Ubiquitin-conjugating Enzyme UBC13
Yusuke Sato et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Ubiquitin-specific Protease 4 Mitigates Toll-like/Interleukin-1 Receptor Signaling and Regulates Innate Immune Activation
FangFang Zhou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
Ying Zhang et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Epstein-Barr Virus BPLF1 Deubiquitinates PCNA and Attenuates Polymerase η Recruitment to DNA Damage Sites
Christopher B. Whitehurst et al.
JOURNAL OF VIROLOGY (2012)
Tandem Protein Interaction Modules Organize the Ubiquitin-Dependent Response to DNA Double-Strand Breaks
Stephanie Panier et al.
MOLECULAR CELL (2012)
OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function
Yu-Chi Juang et al.
MOLECULAR CELL (2012)
ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage
Svetlana V. Khoronenkova et al.
MOLECULAR CELL (2012)
The mechanism of OTUB1-mediated inhibition of ubiquitination
Reuven Wiener et al.
NATURE (2012)
Ubiquitin removal in the TGF-β pathway
Kamna Aggarwal et al.
NATURE CELL BIOLOGY (2012)
USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor
Long Zhang et al.
NATURE CELL BIOLOGY (2012)
UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair
Petra Schwertman et al.
NATURE GENETICS (2012)
Deubiquitinases in cancer: new functions and therapeutic options
J. M. Fraile et al.
ONCOGENE (2012)
Ubiquitin-Specific Protease 4 Inhibits Mono-Ubiquitination of the Master Growth Factor Signaling Kinase PDK1
Iris Z. Uras et al.
PLOS ONE (2012)
The Ubiquitin Peptidase UCHL1 Induces G0/G1 Cell Cycle Arrest and Apoptosis Through Stabilizing p53 and Is Frequently Silenced in Breast Cancer
Tingxiu Xiang et al.
PLOS ONE (2012)
Diverse ubiquitin signaling in NF-κB activation
Kazuhiro Iwai
TRENDS IN CELL BIOLOGY (2012)
Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47
Joseph Weinstock et al.
ACS MEDICINAL CHEMISTRY LETTERS (2012)
Deubiquitinase USP9x Confers Radioresistance through Stabilization of Mcl-1
Donatella Trivigno et al.
NEOPLASIA (2012)
DNA repair dysregulation from cancer driver to therapeutic target
Nicola J. Curtin
NATURE REVIEWS CANCER (2012)
The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance
Peter Bouwman et al.
NATURE REVIEWS CANCER (2012)
An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme
Derek F. Ceccarelli et al.
CELL (2011)
USP1 Deubiquitinates ID Proteins to Preserve a Mesenchymal Stem Cell Program in Osteosarcoma
Samuel A. Williams et al.
CELL (2011)
Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13
Junli Liu et al.
CELL (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Enzymatic Characterisation of USP7 Deubiquitinating activity and Inhibition
Jonathan D. Wrigley et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2011)
SUMO-specific protease 2 in Mdm2-mediated regulation of p53
M. Jiang et al.
CELL DEATH AND DIFFERENTIATION (2011)
The role of deubiquitinating enzymes in apoptosis
Suresh Ramakrishna et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2011)
Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes
Mikael Altun et al.
CHEMISTRY & BIOLOGY (2011)
Selective and Cell-Active Inhibitors of the USP1/UAF1 Deubiquitinase Complex Reverse Cisplatin Resistance in Non-small Cell Lung Cancer Cells
Junjun Chen et al.
CHEMISTRY & BIOLOGY (2011)
Development of Small Molecule Inhibitors and Probes of Human SUMO Deconjugating Proteases
Victoria E. Albrow et al.
CHEMISTRY & BIOLOGY (2011)
Searching for synthetic lethality in cancer
Rachel Brough et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2011)
JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress
Juhong Liu et al.
EMBO JOURNAL (2011)
USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1
Xinna Zhang et al.
EMBO JOURNAL (2011)
Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases
Mariola J. Edelmann et al.
EXPERT REVIEWS IN MOLECULAR MEDICINE (2011)
SUMOylation and de-SUMOylation in response to DNA damage
Hong Dou et al.
FEBS LETTERS (2011)
The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks
Simon Bekker-Jensen et al.
FEBS LETTERS (2011)
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
Sophie E. Polo et al.
GENES & DEVELOPMENT (2011)
USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation
Jean-Hugues Guervilly et al.
HUMAN MOLECULAR GENETICS (2011)
Control of B Cell Development by the Histone H2A Deubiquitinase MYSM1
Xiao-Xia Jiang et al.
IMMUNITY (2011)
The BRCA1-RAP80 Complex Regulates DNA Repair Mechanism Utilization by Restricting End Resection
Kara A. Coleman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage
Xiomaris M. Cotto-Rios et al.
JOURNAL OF CELL BIOLOGY (2011)
Interferon-Stimulated Gene 15 and the Protein ISGylation System
Dongxian Zhang et al.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2011)
The USP1/UAF1 Complex Promotes Double-Strand Break Repair through Homologous Recombination
Junko Murai et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation
Ramesh Ummanni et al.
MOLECULAR CANCER (2011)
USP47 Is a Deubiquitylating Enzyme that Regulates Base Excision Repair by Controlling Steady-State Levels of DNA Polymerase β
Jason L. Parsons et al.
MOLECULAR CELL (2011)
NF-κB Induction of the SUMO Protease SENP2: A Negative Feedback Loop to Attenuate Cell Survival Response to Genotoxic Stress
Moon Hee Lee et al.
MOLECULAR CELL (2011)
Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets
Lynn Bedford et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
USP7/HAUSP stimulates repair of oxidative DNA lesions
Svetlana V. Khoronenkova et al.
NUCLEIC ACIDS RESEARCH (2011)
Overexpression of Ubiquitin Specific Protease 44 (USP44) Induces Chromosomal Instability and Is Frequently Observed in Human T-Cell Leukemia
Ying Zhang et al.
PLOS ONE (2011)
Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis
Vaibhav Kapuria et al.
CANCER RESEARCH (2010)
Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?
Philip Cohen et al.
CELL (2010)
ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks
Niraj M. Shanbhag et al.
CELL (2010)
USP10 Regulates p53 Localization and Stability by Deubiquitinating p53
Jian Yuan et al.
CELL (2010)
Synthesis and Biological Evaluation of 9-Oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile Analogues as Potential Inhibitors of Deubiquitinating Enzymes
Matteo Colombo et al.
CHEMMEDCHEM (2010)
The Tumor Suppressor UCHL1 Forms a Complex with p53/MDM2/ARF to Promote p53 Signaling and Is Frequently Silenced in Nasopharyngeal Carcinoma
Lili Li et al.
CLINICAL CANCER RESEARCH (2010)
The ubiquitous role of ubiquitin in the DNA damage response
Abdallah Al-Hakim et al.
DNA REPAIR (2010)
Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor
Goedele N. Maertens et al.
EMBO JOURNAL (2010)
SENP1 Induces Prostatic Intraepithelial Neoplasia through Multiple Mechanisms
Tasneem Bawa-Khalfe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Sensitivity to Poly(ADP-ribose) Polymerase (PARP) Inhibition Identifies Ubiquitin-specific Peptidase 11 (USP11) as a Regulator of DNA Double-strand Break Repair
Timothy D. Wiltshire et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Regulated Degradation of Spindle Assembly Factors by the Anaphase-Promoting Complex
Ling Song et al.
MOLECULAR CELL (2010)
Three DNA Polymerases, Recruited by Different Mechanisms, Carry Out NER Repair Synthesis in Human Cells
Tomoo Ogi et al.
MOLECULAR CELL (2010)
Regulation of DNA Repair through DeSUMOylation and SUMOylation of Replication Protein A Complex
Hong Dou et al.
MOLECULAR CELL (2010)
Autophagy and the Integrated Stress Response
Guido Kroemer et al.
MOLECULAR CELL (2010)
The DNA Damage Response: Making It Safe to Play with Knives
Alberto Ciccia et al.
MOLECULAR CELL (2010)
The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling
S. Hussain et al.
LEUKEMIA (2010)
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
Martin Schwickart et al.
NATURE (2010)
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1
Shinichiro Nakada et al.
NATURE (2010)
Identification of a novel chemical potentiator and inhibitors of UCH-L1 by in silico drug screening
Takeshi Mitsui et al.
NEUROCHEMISTRY INTERNATIONAL (2010)
The ubiquitin-specific protease USP47 is a novel β-TRCP interactor regulating cell survival
A. Peschiaroli et al.
ONCOGENE (2010)
MdmX is a substrate for the deubiquitinating enzyme USP2a
N. Allende-Vega et al.
ONCOGENE (2010)
Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes
Francisca E. Reyes-Turcu et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins
Carsten Doil et al.
CELL (2009)
Blinded by the Light: The Growing Complexity of p53
Karen H. Vousden et al.
CELL (2009)
DNA damage responses by human ELG1 in S phase are important to maintain genomic integrity
Nilabja Sikdar et al.
CELL CYCLE (2009)
DUBs and cancer The role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors
Sajjad Hussain et al.
CELL CYCLE (2009)
Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection
Marisa K. Isaacson et al.
CELL HOST & MICROBE (2009)
Polyubiquitin Binding and Disassembly By Deubiquitinating Enzymes
Francisca E. Reyes-Turcu et al.
CHEMICAL REVIEWS (2009)
Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells
Richard Buus et al.
CURRENT BIOLOGY (2009)
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2
H. Christian Reinhardt et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
Inactivation of Murine Usp1 Results in Genomic Instability and a Fanconi Anemia Phenotype
Jung Min Kim et al.
DEVELOPMENTAL CELL (2009)
Structural aspects of multi-domain RING/Ubox E3 ligases in DNA repair
Richard G. Hibbert et al.
DNA REPAIR (2009)
Monoubiquitylation in the Fanconi anemia DNA damage response pathway
A. F. Alpi et al.
DNA REPAIR (2009)
Regulatory ubiquitylation in response to DNA double-strand breaks
Stephanie Panier et al.
DNA REPAIR (2009)
Ubiquitin-binding domains and their role in the DNA damage response
Kay Hofmann
DNA REPAIR (2009)
MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks
Genze Shao et al.
GENES & DEVELOPMENT (2009)
Suppression of the Deubiquitinating Enzyme USP5 Causes the Accumulation of Unanchored Polyubiquitin and the Activation of p53
Saurabh Dayal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
USP7 counteracts SCFβTrCP-but not APCCdh1-mediated proteolysis of Claspin
Helene Faustrup et al.
JOURNAL OF CELL BIOLOGY (2009)
The ubiquitin landscape at DNA double-strand breaks
Troy E. Messick et al.
JOURNAL OF CELL BIOLOGY (2009)
The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway
Bin Zhao et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells
Frederic Colland et al.
MOLECULAR CANCER THERAPEUTICS (2009)
The DNA-damage response in human biology and disease
Stephen P. Jackson et al.
NATURE (2009)
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
Teresa A. Soucy et al.
NATURE (2009)
Origin and function of ubiquitin-like proteins
Mark Hochstrasser
NATURE (2009)
Breaking the chains: structure and function of the deubiquitinases
David Komander et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers.
Peter C. Fong et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
MOLECULAR ORIGINS OF CANCER DNA Damage, Aging, and Cancer
Jan H. J. Hoeijmakers
NEW ENGLAND JOURNAL OF MEDICINE (2009)
The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks
Genze Shao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Crosstalk between histone modifications during the DNA damage response
Haico van Attikum et al.
TRENDS IN CELL BIOLOGY (2009)
Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts
Kristin E. Yates et al.
AGING CELL (2008)
Atypical ubiquitin chains: new molecular signals - 'Protein modifications: Beyond the usual suspects' review series
Fumiyo Ikeda et al.
EMBO REPORTS (2008)
The BCL-2 protein family: opposing activities that mediate cell death
Richard J. Youle et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Transcription-coupled DNA repair: two decades of progress and surprises
Philip C. Hanawalt et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Regulation of DNA repair throughout the cell cycle
Dana Branzei et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
An oncogene-induced DNA damage model for cancer development
Thanos D. Halazonetis et al.
SCIENCE (2008)
Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response
Z. Cheng et al.
ONCOGENE (2008)
Deubiquitylation and regulation of the immune response
Shao-Cong Sun
NATURE REVIEWS IMMUNOLOGY (2008)
The DNA damage response pathways: at the crossroad of protein modifications
Michael Sy Huen et al.
CELL RESEARCH (2008)
A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway
Martin A. Cohn et al.
MOLECULAR CELL (2007)
The DNA damage response: Ten years after
J. Wade Harper et al.
MOLECULAR CELL (2007)
Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
Xu Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Deubiquitination of FANCD2 is required for DNA crosslink repair
Vibe H. Oestergaard et al.
MOLECULAR CELL (2007)
Human USP3 is a chromatin modifier required for S phase progression and genome stability
Francesco Nicassio et al.
CURRENT BIOLOGY (2007)
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
Yonghua Yang et al.
NATURE CELL BIOLOGY (2007)
Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening
Kazunori Hirayama et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Regulation of cell cycle progression and gene expression by H2A deubiquitination
Heui-Yun Joo et al.
NATURE (2007)
Fbw7 and Usp28 regulate Myc protein stability in response to DNA damage
Nikita Popov et al.
CELL CYCLE (2007)
A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation
Ping Zhu et al.
MOLECULAR CELL (2007)
SUMO-specific proteases: a twist in the tail
Ronald Thomas Hay
TRENDS IN CELL BIOLOGY (2007)
Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization
Amaury Fernandez-Montalvan et al.
FEBS JOURNAL (2007)
The ubiquitin-specific protease USP28 is required for MYC stability
Nikita Popov et al.
NATURE CELL BIOLOGY (2007)
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites
Bijan Sobhian et al.
SCIENCE (2007)
The spindle-assembly checkpoint in space and time
Andrea Musacchio et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities
Frank Stegmeier et al.
NATURE (2007)
DNA damage checkpoints: from initiation to recovery or adaptation
Jiri Bartek et al.
CURRENT OPINION IN CELL BIOLOGY (2007)
Co-ordination of DNA single strand break repair
Grigory L. Dianou et al.
DNA REPAIR (2007)
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
Lauren F. Stevenson et al.
EMBO JOURNAL (2007)
MDM2 inhibitors for cancer therapy
Lyubomir T. Vassilev
TRENDS IN MOLECULAR MEDICINE (2007)
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP
Armando van der Horst et al.
NATURE CELL BIOLOGY (2006)
The isopeptidase USP2a protects human prostate cancer from apoptosis
Carmen Priolo et al.
CANCER RESEARCH (2006)
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response
Dong Zhang et al.
CELL (2006)
Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth
Anna Lasorella et al.
NATURE (2006)
BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation
Xiaowei Chen et al.
CANCER RESEARCH (2006)
hnRNP K: An HDM2 target and transcriptional coactivator of p53 in response to DNA damage
A Moumen et al.
CELL (2005)
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
E Meulmeester et al.
MOLECULAR CELL (2005)
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
HE Bryant et al.
NATURE (2005)
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
H Farmer et al.
NATURE (2005)
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway
SMB Nijman et al.
MOLECULAR CELL (2005)
A conserved element in Myc that negatively regulates its proapoptotic activity
A Herbst et al.
EMBO REPORTS (2005)
Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin
RM de Oca et al.
BLOOD (2005)
The development of proteasome inhibitors as anticancer drugs
J Adams
CANCER CELL (2004)
Punaglandins, chlorinated prostaglandins, function as potent Michael receptors to inhibit ubiquitin isopeptidase activity
SM Verbitski et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage
AR Schoenfeld et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Initiating cellular stress responses
CJ Bakkenist et al.
CELL (2004)
Δ12-prostaglandin J2 inhibits the ubiquitin hydrolase UCH-L1 and elicits ubiquitin-protein aggregation without proteasome inhibition
ZM Li et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin
XZ Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
A DNA damage checkpoint response in telomere-initiated senescence
FD di Fagagna et al.
NATURE (2003)
Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair
YS Dong et al.
MOLECULAR CELL (2003)
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line
YC Liu et al.
CHEMISTRY & BIOLOGY (2003)
p53 binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice
IM Ward et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
The complex matter of DNA double-strand break detection
JM Bradbury et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2003)
53BP1, a mediator of the DNA damage checkpoint
B Wang et al.
SCIENCE (2002)
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51
T Taniguchi et al.
BLOOD (2002)
Gene expression profiles, of BRCA1-linked, BRCA2-linked, and sporadic ovarian cancers
AA Jazaeri et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2002)
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
MY Li et al.
NATURE (2002)
Id proteins at the cross-road of development and cancer
A Lasorella et al.
ONCOGENE (2001)
Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences
A Tutt et al.
EMBO JOURNAL (2001)
Protein regulation by monoubiquitin
L Hicke
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)
BRCA2 is required for homology-directed repair of chromosomal breaks
ME Moynahan et al.
MOLECULAR CELL (2001)
Ubiquitination and deubiquitination: Targeting of proteins for degradation by the proteasome
KD Wilkinson
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2000)
Share Paper
