Journal
CELL BIOCHEMISTRY AND BIOPHYSICS
Volume 68, Issue 2, Pages 241-246Publisher
HUMANA PRESS INC
DOI: 10.1007/s12013-013-9702-9
Keywords
Bladder cancer cells; Specific membrane capacitance (SMC); Young's modulus; Microfluidics; Atomic force microscopy (AFM)
Funding
- Natural Sciences and Engineering Research Council of Canada
- Canada Research Chairs Program
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Specific membrane capacitance (SMC) and Young's modulus are two important parameters characterizing the biophysical properties of a cell. In this work, the SMC and Young's modulus of two cell lines, RT4 and T24, corresponding to well differentiated (low grade) and poorly differentiated (high grade) urothelial cell carcinoma (UCC), respectively, were quantified using microfluidic and AFM measurements. Quantitative differences in SMC and Young's modulus values of the high-grade and low-grade UCC cells are, for the first time, reported.
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