Journal
NEUROIMAGE
Volume 18, Issue 1, Pages 1-9Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/nimg.2002.1314
Keywords
cerebral blood flow; functional activation; laser-Doppler flowmetry; nitric oxide; nitric oxide synthase; nitric oxide microelectrode
Funding
- NEI NIH HHS [EY09269] Funding Source: Medline
- NIMH NIH HHS [MH59934, MH12078] Funding Source: Medline
- NINDS NIH HHS [NS337859] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY009269] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH059934, F30MH012078] Funding Source: NIH RePORTER
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We report the first dynamic measurements of tissue nitric oxide (NO) during functional activation of rat somatosensory cortex by electrical forepaw stimulation. Cortical tissue NO was measured electrochemically with rapid-responding recessed microelectrodes (tips < 10 mum). Simultaneous blood flow measurements were made by laser-Doppler flowmetry (LDF). NO immediately increased, reaching a peak 125.5 +/- 32.8 (SE) nM above baseline (P < 0.05) within 400 ms after stimulus onset, preceding any LDF changes, and then returned close to prestimulus levels after 2 s (123 signal-averaged trials, 12 rats). Blood flow began rising after a 1-s delay, reaching a peak just before electrical stimulation was ended at t = 4 s. A consistent poststimulus NO undershoot was observed as LDF returned to baseline. These findings complement our previous study (B. M. Ances et aL, 2001, Neurosci. Lett. 306,106-110) in which a transient decrease in rat somatosensory cortex tissue oxygen partial pressure was found to precede blood flow increases during functional activation. (C) 2002 Elsevier Science (USA).
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