Journal
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Volume 17, Issue 14, Pages 1517-1527Publisher
WILEY
DOI: 10.1002/rcm.1030
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Electrospray ionization mass spectrometry (ESI-MS) coupled to liquid chromatography (LC) has been applied to investigate cisplatin and its hydrated complexes. Three hydrolysis products were identified following incubation of cisplatin in aqueous solution: monohydrated species, dihydrated species and the hydroxo-bridged dimer, each of which exhibited characteristic mass spectrometric behavior. The technique was employed to investigate the time- and pH-dependent hydrolysis of cisplatin in aqueous solution. The results have demonstrated that LC/ESI-MS is a powerful technique for the analysis of Pt(II) complexes and for monitoring their hydrolysis reactions. Copyright (C) 2003 Crown in the right of Canada. Published by John Wiley Sons, Ltd.
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