Journal
CELL BIOCHEMISTRY AND BIOPHYSICS
Volume 60, Issue 1-2, Pages 61-68Publisher
HUMANA PRESS INC
DOI: 10.1007/s12013-011-9185-5
Keywords
USP7; HAUSP; Deubiquitylase; Cancer; Ubiquitin
Funding
- NCI NIH HHS [CA115205] Funding Source: Medline
- NIDDK NIH HHS [DK071391] Funding Source: Medline
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The deubiquitylating enzyme USP7 (HAUSP) sits at a critical node regulating the activities of numerous proteins broadly characterized as tumor suppressors, DNA repair proteins, immune responders, viral proteins, and epigenetic modulators. Aberrant USP7 activity may promote oncogenesis and viral disease making it a compelling target for therapeutic intervention. Disclosed drug discovery programs have identified inhibitors of USP7 such as P005091 with cellular proof of concept and anti-proliferative activity in cancer models. Taken together, USP7 inhibitors hold promise as a new strategy for the treatment of disease.
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