Journal
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Volume 17, Issue 15, Pages 1709-1713Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/rcm.1109
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This paper reports development of a non-mechanical electrospray ionization (ESI) method to generate electrospray from a droplet deposited on an optical fiber coated with a thin gold or Nafion film. Modification of the surface of the optical fiber in this manner increases its wettability, such that a droplet of the aqueous sample solution can adhere sufficiently strongly to the tip of the fiber. The aqueous sample solution was deposited near the tip of the fiber with a micropipette. When a high voltage (2000 V) was applied to the fiber by electrical connection through the gold film, the sample solution moved and hung at the tip of the fiber. Simultaneously, ESI was generated from the sample droplet. Multiply charged peptide and protein ions were detected by connecting the ESI source to a quadrupole mass analyzer. Copyright (C) 2003 John Wiley Sons, Ltd.
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