Journal
CELL BIOCHEMISTRY AND BIOPHYSICS
Volume 51, Issue 2-3, Pages 81-87Publisher
HUMANA PRESS INC
DOI: 10.1007/s12013-008-9016-5
Keywords
kidney mitochondria; permeability transition; N-ethylmaleimide; carboxyatractyloside; agaric acid; oleate; fatty acids
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In this work, we studied the effect of N-ethylmaleimide on permeability transition. The findings indicate that the amine inhibited the effects of carboxyatractyloside and agaric acid. It is known that these reagents interact with the adenine nucleotide carrier through the cytosolic side. When oleate, which interacts through the matrix side, was used it was found that the amine amplified the effects of oleate on permeability transition. The results also show that N-ethylmaleimide strengthened the inhibition induced by carboxyatractyloside, agaric acid, and oleate on ADP exchange. Furthermore, it was also found that oleate improved the binding of eosin-5-maleimide on the adenine nucleotide translocase.
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