Journal
LEUKEMIA & LYMPHOMA
Volume 44, Issue 3, Pages 531-533Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/1042819021000035662
Keywords
gammadelta T-cell lymphoma; hjepatosplenomegaly; Crohn's disease; azathioprine
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Hepatosplenic gammadelta T-cell lymphoma (HSgammadeltaTCL) is an uncommon type of peripheral T-cell lymphoma, which has been associated in some cases with immunosuppression, mainly after solid organ transplants. We describe a case of HSgammadeltaTCL with a leukaemic course in a patient with Crohn's disease who had received azathioprine during the previous 55 years. Sinusoidal infiltration by atypical lymphocytes was observed in the liver, spleen and bone marrow and the typical cytogenetic abnormalities (isochromosome 7 and trisomy 8) were found. The patient did not respond to intensive chemotherapy. This case shows the importance of ruling out HSgammadeltaTCL in patients with hepatosplenomegaly, B-symptoms and any immunosuppressive condition.
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