Journal
CELL AND TISSUE RESEARCH
Volume 355, Issue 3, Pages 701-715Publisher
SPRINGER
DOI: 10.1007/s00441-014-1820-1
Keywords
Tight junction; JAM; Polarity; Leukocyte migration; Inflammation
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Funding
- Swiss National Science Foundation [31003AB_135701]
- ONCOSUISSE [KFS 2914-02-2012]
- Swiss National Science Foundation (SNF) [31003AB_135701] Funding Source: Swiss National Science Foundation (SNF)
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Junctional adhesion molecules (JAMs) are a family of adhesion molecules localized at the tight junction of polarized cells and on the cell surface of leukocytes. The last 20 years of research in this field has shown that several members of the family play an important role in the regulation of cell polarity, endothelium permeability and leukocytes migration. They mediate these pleiotropic functions through a multitude of homophilic and heterophilic interactions with intrafamily and extrafamily partners. In this article, we review the current status of the JAM family and highlight their functional role in tight junction dynamics and leukocyte transmigration.
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