Journal
CELL AND TISSUE RESEARCH
Volume 360, Issue 3, Pages 685-699Publisher
SPRINGER
DOI: 10.1007/s00441-014-2078-3
Keywords
Connexins; Gap junctions; Proliferation; Cell cycle; Cancer
Categories
Funding
- Instituto de Salud Carlos III [PI13/00763, CP10/00624]
- European Regional Development Fund (ERDF)
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Mounting evidence indicates that dysregulation of gap junctions and their structural subunits-connexins-often occurs in, and sometimes causes, a variety of proliferative disorders, including cancer. Connexin-mediated regulation of cell proliferation is complex and may involve modulation of gap junction intercellular communication (GJIC), hemichannel signalling, or gap junction-independent paths. However, the exact mechanisms linking connexins to proliferation remain poorly defined and a number of contradictory studies report both pro-and anti-proliferative effects, effects that often depend on the cell or tissue type or the microenvironment. The present review covers junctional and non-junctional regulation of proliferation by connexins, with a particular emphasis on their association with cancer.
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