Journal
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
Volume 23, Issue 15, Pages 2905-2919Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0955-2219(03)00302-9
Keywords
biomedical applications; heterogeneous nucleation; hydrogel-CP composite; interfacial adhesion
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We report a template-driven nucleation and mineral growth process for the high-affinity integration of calcium phosphate (CP) with a poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel scaffold. A mineralization technique was developed that exposes carboxylate groups on the surface of crosslinked pHEMA, promoting high-affinity nucleation and growth Of calcium phosphate oil the surface along with extensive calcification of the hydrogel interior. External factors such as the heating rate, the agitation of the mineral stock solution and the duration of the process that affect the Outcome of the mineralization were investigated. This template-driven mineralization technique provides an efficient approach toward bonelike composites with high mineral-hydrogel interfacial adhesion strength. (C) 2003 Elsevier Ltd. All rights reserved.
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