Journal
ARTHRITIS RESEARCH & THERAPY
Volume 5, Issue 5, Pages 235-238Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/ar991
Keywords
biomaterials; cartilage; mesenchymal progenitor cells; tissue engineering
Categories
Funding
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [Z01AR041131, ZIAAR041131] Funding Source: NIH RePORTER
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Damage to cartilage is of great clinical consequence given the tissue's limited intrinsic potential for healing. Current treatments for cartilage repair are less than satisfactory, and rarely restore full function or return the tissue to its native normal state. The rapidly emerging field of tissue engineering holds great promise for the generation of functional cartilage tissue substitutes. The general approach involves a biocompatible, structurally and mechanically sound scaffold, with an appropriate cell source, which is loaded with bioactive molecules that promote cellular differentiation and/or maturation. This review highlights aspects of current progress in cartilage tissue engineering.
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