Journal
JOURNAL OF CELL SCIENCE
Volume 116, Issue 1, Pages 17-27Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.00167
Keywords
nectin; afadin; adherens junctions; tight junctions; puncta adherentia junctions; Sertoli-cell-spermatid junctions
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The cadherin superfamily plays key roles in intercellular adhesion. An emerging intercellular adhesion system, consisting of nectin and afadin, also has roles in organization of a variety of intercellular junctions either in cooperation with, or independently of, cadherin. Nectin is a Ca2+-independent immunoglobulin-like intercellular adhesion molecule, and afadin is a nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. This novel intercellular adhesion system has roles in the organization of E-cadherin-based adherens junctions and claudin-based tight junctions in epithelial cells. The adhesion system is furthermore involved in the formation of synapses in neurons and the organization of heterotypic junctions between Sertoli cells and spermatids in the testis.
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