Journal
CELL AND TISSUE RESEARCH
Volume 354, Issue 3, Pages 887-889Publisher
SPRINGER
DOI: 10.1007/s00441-013-1699-2
Keywords
Low density receptor-related protein 1; Anti-inflammatory activity; Macrophage; Mouse
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG) [MA2410/1-2-4]
- Bundesministerium fur Bildung und Forschung (BMBF)
- Center for Laboratory Medicine
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We have previously reported that apolipoprotein E (apoE), a protein component of very-low-density lipoproteins (VLDL) and high-density lipoproteins and a potent plasma-borne atheroprotective factor, exerts anti-inflammatory activity in macrophages by switching the activation profile from M1 (classic) to M2 (alternative) in a process involving signaling via low-density lipoprotein receptor (LDLR) family members including the VLDL receptor (VLDLR) or apoE receptor-2 (apoER2). The present study was undertaken to investigate whether LDLR-related protein 1 (LRP-1), another member of the LDLR family and a ubiquitously expressed multifunctional cell surface receptor, modulates M1 -> M2 conversion in murine macrophages. We investigate bone marrow or peritoneal macrophages isolated from wild-type C57/Bl6 mice or mice with conditional inactivation of the LRP-1 gene in the myeloid lineage for the expression of polarization markers. Our results suggest that the deficiency of LRP-1 down-regulates M2 marker expression in macrophages, while enhancing the macrophage response to M1 stimuli. To our knowledge, this is the first demonstration that LRP-1 affects macrophage polarization and promotes the development of an anti-inflammatory M2 functional phenotype.
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