Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 136, Issue 5, Pages 474-477Publisher
CONSULTANTS BUREAU
DOI: 10.1023/B:BEBM.0000017097.75818.14
Keywords
Alzheimer disease; memantine; dimebon; action mechanism; glutamate receptors
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Dimebon in low concentrations potentiated activity of AMPA-receptors in rat cerebellar Purkinje neurons, while memantine produced only an insignificant potentiation in a small group of these cells. In cortical neurons of rat brain memantine efficiently blocked NMDA induced currents in dimebon-insensitive neurons. By contrast, its effect was far weaker in neurons, where the blocking action of dimebon on NMDA-receptors was most pronounced. It was hypothesized that the differences in the effects of memantine and dimebon are determined by their interaction with different sites of NMDA-receptors.
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